Epigenetic genome control by RNA-based mechanisms

Abstract: Genome-wide sequencing of the human genome and several model organisms has greatly facilitated research into genome structure and function. Much attention is now focused on understanding how the functional organization of the genome supports translation of genetic information into formation of different cell types during development, and how it contributes to disease progression. We have shown previously that distinct histone methylation patterns organize chromosomes into “open” euchromatin (H3K4me) and “closed” heterochromatin (H3K9me) domains, to modulate use of the genome. Our work has also revealed that heterochromatin can be targeted by RNAi machinery and/or by pathways requiring RNA elimination and transcription termination factors. Moreover, we find that RNA processing factors and heterochromatin machinery are part of an adaptive cellular mechanisms that can reprogram the genome in response to changes in environmental growth conditions and developmental signals. Our most recent work on the assembly and epigenetic inheritance of silenced chromatin domains, essential for proper gene regulation during development will be presented.

biochemistrycancer biologychemical biologycell biologydevelopmental biologydrug discoveryevolutiongeneticsimmunologymolecular biologymicrobiologyneuroscienceplant sciencessystems biologybiotechnologybiological techniquesbiophysics

Audience: researchers in the discipline

( video )

Comments: The organizers can be contacted at 22100032@lums.edu.pk for the zoom link.

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Colloquium zooming Molecular & Cellular Biology LUMS

Series comments: Zooming Molecular & Cellular Biology Colloquium was initiated on July 28th, 2020 by the Biology department at Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS). The series follows through various topics which come under the ambit of Molecular and Cellular Biology and we’ve had the pleasure and honor of hosting some of the most knowledgeable scientists from around the globe. Organizers can be reached out at 24100162@lums.edu.pk or 24100001@lums.edu.pk for the Zoom link of individual talks. All lectures are LIVE streamed on SBASSE's official Facebook page.

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